10. Enter the index of the starting dose level.
**Note:**
Index of
lowest
dose level is always 1. If the design allows for
*'minus'*
dose levels (i.e. -2, -1, etc.), then the index of the starting dose should account for these lower levels (i.e. if -1 dose level allowed, index of starting dose is 2.)

**This application simulates operating characteristics for the early-phase method of Wages and Fadul [1].**

[1] Wages NA, Fadul CE (2019). Adaptive dose finding based on safety and feasibility in early-phase clinical trials of adoptive cell immunotherapy.
*Clin Trials;*
[epub ahead of print] Dec 20.

**This application computes an updated planned dose level for the next patient in a phase I trial according to the Wages and Fadul method [1].**

[1] Wages NA, Fadul CE (2019). Adaptive dose finding based on safety and feasibility in early-phase clinical trials of adoptive cell immunotherapy.
*Clin Trials;*
[epub ahead of print] Dec 20.

**This application computes the safety stopping bounds for the lowest study dose level computed from the posterior distribution of the DLT rate at the lowest dose level based on a beta prior distribution.**

**This application computes the feasibility stopping bounds computed from the posterior distribution of the feasbility rate at the lowest dose level based on a beta prior distribution.**